Antiviral Terpenoid Constituents of Ganoderma pfeifferi.
Identifieur interne : 000503 ( Main/Exploration ); précédent : 000502; suivant : 000504Antiviral Terpenoid Constituents of Ganoderma pfeifferi.
Auteurs : Timo H J. Niedermeyer [Allemagne] ; Ulrike Lindequist ; Renate Mentel ; Dirk Gördes ; Enrico Schmidt ; Kerstin Thurow ; Michael LalkSource :
- Journal of natural products [ 0163-3864 ] ; 2005.
Descripteurs français
- KwdFr :
- Allemagne, Antibactériens (), Antibactériens (isolement et purification), Antibactériens (pharmacologie), Antifongiques (), Antifongiques (isolement et purification), Antifongiques (pharmacologie), Antiviraux (), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Ganoderma (), Relation structure-activité, Simplexvirus (), Structure moléculaire, Stérols (), Stérols (isolement et purification), Stérols (pharmacologie), Terpènes (), Terpènes (isolement et purification), Terpènes (pharmacologie), Tests de sensibilité microbienne, Virus de la grippe A ().
- MESH :
- isolement et purification : Antibactériens, Antifongiques, Antiviraux, Stérols, Terpènes.
- pharmacologie : Antibactériens, Antifongiques, Antiviraux, Stérols, Terpènes.
- Allemagne, Antibactériens, Antifongiques, Antiviraux, Ganoderma, Relation structure-activité, Simplexvirus, Structure moléculaire, Stérols, Terpènes, Tests de sensibilité microbienne, Virus de la grippe A.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (isolation & purification), Anti-Bacterial Agents (pharmacology), Antifungal Agents (chemistry), Antifungal Agents (isolation & purification), Antifungal Agents (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Ganoderma (chemistry), Germany, Influenza A virus (drug effects), Microbial Sensitivity Tests, Molecular Structure, Simplexvirus (drug effects), Sterols (chemistry), Sterols (isolation & purification), Sterols (pharmacology), Structure-Activity Relationship, Terpenes (chemistry), Terpenes (isolation & purification), Terpenes (pharmacology).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Antifungal Agents, Antiviral Agents, Sterols, Terpenes.
- chemical , isolation & purification : Anti-Bacterial Agents, Antifungal Agents, Antiviral Agents, Sterols, Terpenes.
- chemical , pharmacology : Anti-Bacterial Agents, Antifungal Agents, Antiviral Agents, Sterols, Terpenes.
- geographic : Germany.
- chemistry : Ganoderma.
- drug effects : Influenza A virus, Simplexvirus.
- Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship.
Abstract
Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.
DOI: 10.1021/np0501886
PubMed: 16378363
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Niedermeyer</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Lindequist, Ulrike" sort="Lindequist, Ulrike" uniqKey="Lindequist U" first="Ulrike" last="Lindequist">Ulrike Lindequist</name></author><author><name sortKey="Mentel, Renate" sort="Mentel, Renate" uniqKey="Mentel R" first="Renate" last="Mentel">Renate Mentel</name></author><author><name sortKey="Gordes, Dirk" sort="Gordes, Dirk" uniqKey="Gordes D" first="Dirk" last="Gördes">Dirk Gördes</name></author><author><name sortKey="Schmidt, Enrico" sort="Schmidt, Enrico" uniqKey="Schmidt E" first="Enrico" last="Schmidt">Enrico Schmidt</name></author><author><name sortKey="Thurow, Kerstin" sort="Thurow, Kerstin" uniqKey="Thurow K" first="Kerstin" last="Thurow">Kerstin Thurow</name></author><author><name sortKey="Lalk, Michael" sort="Lalk, Michael" uniqKey="Lalk M" first="Michael" last="Lalk">Michael Lalk</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16378363</idno><idno type="pmid">16378363</idno><idno type="doi">10.1021/np0501886</idno><idno type="wicri:Area/Main/Corpus">000501</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000501</idno><idno type="wicri:Area/Main/Curation">000501</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000501</idno><idno type="wicri:Area/Main/Exploration">000501</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiviral Terpenoid Constituents of Ganoderma pfeifferi.</title><author><name sortKey="Niedermeyer, Timo H J" sort="Niedermeyer, Timo H J" uniqKey="Niedermeyer T" first="Timo H J" last="Niedermeyer">Timo H J. 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The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16378363</PMID><DateCompleted><Year>2006</Year><Month>01</Month><Day>18</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0163-3864</ISSN><JournalIssue CitedMedium="Print"><Volume>68</Volume><Issue>12</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of natural products</Title><ISOAbbreviation>J. Nat. Prod.</ISOAbbreviation></Journal><ArticleTitle>Antiviral Terpenoid Constituents of Ganoderma pfeifferi.</ArticleTitle><Pagination><MedlinePgn>1728-31</MedlinePgn></Pagination><Abstract><AbstractText>Four sterols and 10 triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, antifungal, and antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Niedermeyer</LastName><ForeName>Timo H J</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindequist</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Mentel</LastName><ForeName>Renate</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Gördes</LastName><ForeName>Dirk</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Enrico</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Thurow</LastName><ForeName>Kerstin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Lalk</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nat Prod</MedlineTA><NlmUniqueID>7906882</NlmUniqueID><ISSNLinking>0163-3864</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013261">Sterols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013729">Terpenes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032902" MajorTopicYN="N">Ganoderma</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018139" MajorTopicYN="N">Simplexvirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013261" MajorTopicYN="N">Sterols</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013729" MajorTopicYN="N">Terpenes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>12</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>1</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>12</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16378363</ArticleId><ArticleId IdType="doi">10.1021/np0501886</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Gordes, Dirk" sort="Gordes, Dirk" uniqKey="Gordes D" first="Dirk" last="Gördes">Dirk Gördes</name><name sortKey="Lalk, Michael" sort="Lalk, Michael" uniqKey="Lalk M" first="Michael" last="Lalk">Michael Lalk</name><name sortKey="Lindequist, Ulrike" sort="Lindequist, Ulrike" uniqKey="Lindequist U" first="Ulrike" last="Lindequist">Ulrike Lindequist</name><name sortKey="Mentel, Renate" sort="Mentel, Renate" uniqKey="Mentel R" first="Renate" last="Mentel">Renate Mentel</name><name sortKey="Schmidt, Enrico" sort="Schmidt, Enrico" uniqKey="Schmidt E" first="Enrico" last="Schmidt">Enrico Schmidt</name><name sortKey="Thurow, Kerstin" sort="Thurow, Kerstin" uniqKey="Thurow K" first="Kerstin" last="Thurow">Kerstin Thurow</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Niedermeyer, Timo H J" sort="Niedermeyer, Timo H J" uniqKey="Niedermeyer T" first="Timo H J" last="Niedermeyer">Timo H J. 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